Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4079 | 4079-30225 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A, I84V, L90M | L10I, N37D, I62V, L63P, A71V, I72V, T74S, V77I, I93L |
| >4079-30225| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIVGIGGFAKVRQYD QVPIEICGHKVVGSVLIGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | K103N, Y181C, G190A | K20R, V35I, D121H, K122E, I135T, Q174A, D177E, T200A, E203A, Q207E, L228H, V245VE, A272P, K277R, T286P, A288S, P294T, E297K, I326V, Q334L, N348T, R356K, G359S, A360T, T377N, T386I, K390R, E399D |
| >4079-30225| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKANPEIVI CQYVDDLYVASDLEIGQHRAKIAELREHLLRWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKSLTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKTLKTGKYAKMRST HTNDVKQLTEAVQKIANESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |