Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4078 | 4078-30225 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82F, I84V, L90M | L23I, L33F | L10V, I13V, L19V, E35D, M36L, N37D, F53FY, Q61QE, I62V, T74E, L89M |
| >4078-30225| codons 1-99 PQITLWQRPVVTVKIGGQVKEAILDTGADDTVFEDLDLPGRWKPKLIGGIGGYLKVRQYD EVLIEICGHKAIGEVLVGPTPFNVIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | E6D, V35M, T39TA, E40F, K43E, V118I, S162D, V179I, Q207D, H208Y, R211K, V245E, A272P, I293V, E297EK, I329V, G359GS, A371V, E399ED | D113DE |
| >4078-30225| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGEAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRDYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |