Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4077 | 4077-30225 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84IV, L90M | L33F, F53L, Q58E, G73GS | L10I, K20R, E35D, M36I, N37ND, R41RK, K55R, I62V, L63P, I66V, A71V, I72IT, Q92K, I93IL, C95FL |
| >4077-30225| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGLVRVREYD QVPIEVCGHKVTSTVLVGPTPANVIGRNLMTKLGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219E | K101E, Y181C, G190A | V108I | T39TA, V118I, K122E, Q174R, T200A, E203K, Q207DE, R211K, D218E, Q278H, T286P, I293V, E297R, K311R, I329V, Q334L, G359S, A371V, A376CS, T377L | L228NS |
| >4077-30225| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYVDDLYVASDLEIGQHRAKIKELREHLWKWGFYTPEEKHQKEPPFSWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGPKALTEVVPLTREAE LELAENREILREPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISLESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |