<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4076 4076-30220 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184MV, L210W, T215Y   K103N, Y181C, G190A A98G S3C, P9PQ, K20KR, V35I, T39A, K43E, E44A, V106I, V118I, K122E, Q174QK, V189I, T200A, E203D, H208Y, R211K, W212M, K223Q, L228H, L283LI, I293V, E312EQ, S322T, D324E, I329L, A355E, M357T, K390R  
>4076-30220| codons 1-399
PICPIETVQVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI
CQYVDDLYIASDLEIGQHRAKIDELRQYLWKMGFYTPDKKHQQEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKQPVHGVYYDPTKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYERTRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, K43T, F53L L10I, T12P, K20R, E35D, M36I, N37ND, K55R, R57RK, L63P, I64V, A71V, T74S, I93L  
>4076-30220| codons 1-99
PQITLWQRPIVPIKIGGQLREALIDTGADDTVLEDIDLPGRWTPKLIGGIGGLVRVKQYD
QIPVEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006