Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4076 | 4076-30220 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184MV, L210W, T215Y | K103N, Y181C, G190A | A98G | S3C, P9PQ, K20KR, V35I, T39A, K43E, E44A, V106I, V118I, K122E, Q174QK, V189I, T200A, E203D, H208Y, R211K, W212M, K223Q, L228H, L283LI, I293V, E312EQ, S322T, D324E, I329L, A355E, M357T, K390R |
| >4076-30220| codons 1-399 PICPIETVQVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI CQYVDDLYIASDLEIGQHRAKIDELRQYLWKMGFYTPDKKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKQPVHGVYYDPTKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYERTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, K43T, F53L | L10I, T12P, K20R, E35D, M36I, N37ND, K55R, R57RK, L63P, I64V, A71V, T74S, I93L |
| >4076-30220| codons 1-99 PQITLWQRPIVPIKIGGQLREALIDTGADDTVLEDIDLPGRWTPKLIGGIGGLVRVKQYD QIPVEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |