Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4075 | 4075-30220 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, L90M | L33F, M46V, G73T | L10I, E34Q, L63P, C67F, H69Q, A71IT, I72V, V75I, V77I |
| >4075-30220| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKVVGGIGGFMKVRQYD QIPIEIFGQKTVTTILIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_VT, L74LV, T215Y | D67E | Y181IV, G190A | K20R, V35E, K64KR, K101Q, K122E, I135L, T139R, I142T, V179I, E224D, V245K, L283I, T286P, A288S, I293V, E297R, K366R, A376C, T386I, K390R |
| >4075-30220| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALEEICTELEKEGKISKIGPENPYNTPV FAIRKKESTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNERPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII VQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGPKSLTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEAVQKICTESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |