Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4074 | 4074-30219 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K103N | E6EK, E28EK, K43Q, A98S, K122E, I135T, K166R, G196E, I202V, V245MT, Q278E, I293V, E297R, D324E, I329L, K347Q, R356K, G359S, S379C |
| >4074-30219| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFQNLKTGKYAKMRSA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, L90M | L33F, F53L | T4P, T12P, I13V, K14R, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71L, I72M, V82I, I93L, C95F |
| >4074-30219| codons 1-99 PQIPLWQRPLVPVRIGGQLREALLDTGADDTVFEDISLPGKWKPKLIGGIGGLVKVRQYD QVPIEICGHKLMGTVVVGPTPINIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |