<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4074 4074-30219 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y   K103N   E6EK, E28EK, K43Q, A98S, K122E, I135T, K166R, G196E, I202V, V245MT, Q278E, I293V, E297R, D324E, I329L, K347Q, R356K, G359S, S379C  
>4074-30219| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFQNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, L90M L33F, F53L T4P, T12P, I13V, K14R, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71L, I72M, V82I, I93L, C95F  
>4074-30219| codons 1-99
PQIPLWQRPLVPVRIGGQLREALLDTGADDTVFEDISLPGKWKPKLIGGIGGLVKVRQYD
QVPIEICGHKLMGTVVVGPTPINIIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006