Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2083 | CA7711 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 104 |
| 2 | AZT+ 3TC+ SQV | 17 |
| 3 | AZT+ 3TC+ IDV | 24 |
| 4 | DDI+ D4T+ IDV | 35 |
| 5 | 3TC+ D4T+ NVP | 23 |
| 6 | DLV+ SQV+ NFV | 29 |
| 7 | DLV+ D4T+ IDV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73C | L10I, K20I, D60E, L63Q, I64V, V77I, I85V |
| >CA7711| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYE QIQVEICGHKAICTVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103N, Y181YC | V108VI, K238KT | V35VI, K43N, E44D, S48E, V118I, K122P, K166R, D177E, G196E, R211K, H221HY, V245E, A272P |
| >CA7710| codons 1-274 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKIEKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDTWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGI |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |