Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4072 | 4072-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Y115F, Q151M, M184V | K70S, V75I, F77L, F116Y, T215C, K219Q | Y181C, G190A | P4T, K20R, V35R, T39A, S68G, T69N, K101Q, K122E, S162A, R172K, T200I, D218E, L228H, V245K, A272P, K277R, V292I, I293V, E297K, Q334L, A376S, T386I, K390R |
| >4072-30218| codons 1-399 PISTIETVPVKLKPGMDGPRVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV FAIKKKNGNSWRKLIDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFKKQNPDIVI CQYVDDLYVASDLEIGQHRIKIEELRQHLLRWGFCTPEQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54L, V82F, L90M | L33I, Q58E, N88D | L10IV, I13A, K20R, A22V, E35D, M36I, N37E, R57K, D60N, Q61E, L63P, I64V, A71V, I72M, V75I, I93L |
| >4072-30218| codons 1-99 PQITLWQRPVVTAKIGGQLREVLLDTGADNTVIEDIELPGRWKPKIIGGIGGFLKVKEYN EIPVEICGHKVMGTILVGPTPFNIIGRDLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |