<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4072 4072-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N, M46I, I54L, V82F, L90M L33I, Q58E, N88D L10IV, I13A, K20R, A22V, E35D, M36I, N37E, R57K, D60N, Q61E, L63P, I64V, A71V, I72M, V75I, I93L  
>4072-30218| codons 1-99
PQITLWQRPVVTAKIGGQLREVLLDTGADNTVIEDIELPGRWKPKIIGGIGGFLKVKEYN
EIPVEICGHKVMGTILVGPTPFNIIGRDLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, Y115F, Q151M, M184V K70S, V75I, F77L, F116Y, T215C, K219Q Y181C, G190A   P4T, K20R, V35R, T39A, S68G, T69N, K101Q, K122E, S162A, R172K, T200I, D218E, L228H, V245K, A272P, K277R, V292I, I293V, E297K, Q334L, A376S, T386I, K390R  
>4072-30218| codons 1-399
PISTIETVPVKLKPGMDGPRVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV
FAIKKKNGNSWRKLIDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFKKQNPDIVI
CQYVDDLYVASDLEIGQHRIKIEELRQHLLRWGFCTPEQKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006