Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4071 | 4071-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V75L, F77L | K103S, G190A | Y318F | V35M, E40F, K43E, K49KR, V118I, K122E, I135T, Q207E, L228H, Q242H, V245E, K277R, R284K, T286A, I293V, E297K, A376S, S379C, K390R |
| >4071-30218| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTFLEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLLDLRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVPLTKEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKISTECIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82C, L90M | L10F, V11VI, F53L | K14R, I15V, I62V, L63P, A71V, I72L, I85V |
| >4071-30218| codons 1-99 PQITLWQRPFITIRVGGQLKEALLDTGADDTILEEMNLPGRWKPKIVGGIGGLVKVRQYD QVPIEICGHKVLGTVLVGPTPCNIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |