<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4071 4071-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82C, L90M L10F, V11VI, F53L K14R, I15V, I62V, L63P, A71V, I72L, I85V  
>4071-30218| codons 1-99
PQITLWQRPFITIRVGGQLKEALLDTGADDTILEEMNLPGRWKPKIVGGIGGLVKVRQYD
QVPIEICGHKVLGTVLVGPTPCNIVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y V75L, F77L K103S, G190A Y318F V35M, E40F, K43E, K49KR, V118I, K122E, I135T, Q207E, L228H, Q242H, V245E, K277R, R284K, T286A, I293V, E297K, A376S, S379C, K390R  
>4071-30218| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTFLEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLLDLRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VHPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVPLTKEAE
LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKISTECIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006