Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4063 | 4063-30402 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V, L90M | L10F, L33F, G73S | T12Q, I13V, K20R, E35D, M36V, N37D, K43Q, I62V, L63P, K70E, A71T, I72T, V77I |
| >4063-30402| codons 1-99 PQITLWQRPFVQVKIGGQLREALLDTGADDTIFEDVDLPGRWQPKIVGGIGGFIKVRQYD QVPIEICGHETTSTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L210W, T215Y | K219E | K103N, G190A | Y318YF | V35T, T39A, V106VI, K122E, D123N, I135T, I142V, I195L, T200A, I202V, E203D, H208Y, R211K, V245T, T286A, E297R, V317A, I329L, T386I, E399D |
| >4063-30402| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLELGQHRAKVDELRQYLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGAFYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |