<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4062 4062-30402 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F V75T, K219Q, N348I     P1L, V35T, K64H, V118I, K122E, D123E, I142V, E169D, I178L, I202V, F214L, L228H, A272S, I293V, P294S, E312T, I341IF, G359S, K366R, A371V, K385R, A400T  
>4062-30402| codons 1-400
LISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIHKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVSLTEEAE
LELAENREILKTPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYARMRSA
HTNDVRQLTEVVQKIATESIVIWGRTPKFKLPIQKETWET

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82A, L90M L33F, G73S L10I, E34Q, N37H, R41K, I62V, L63P, C67W, A71V, I72F, V77I, I93L, C95V  
>4062-30402| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKMIGGIGGFAKVRQYD
QVPIEIWGHKVFSTVLIGPTPANIIGRNLMTQLGVTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006