<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4062 4062-30402 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82A, L90M L33F, G73S L10I, E34Q, N37H, R41K, I62V, L63P, C67W, A71V, I72F, V77I, I93L, C95V  
>4062-30402| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKMIGGIGGFAKVRQYD
QVPIEIWGHKVFSTVLIGPTPANIIGRNLMTQLGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F V75T, K219Q, N348I     V35T, K64H, V118I, K122E, D123E, I142V, E169D, I178L, I202V, F214L, L228H, A272S, I293V, P294S, E312T, I341IF, G359S, K366R, A371V, K385R  
>4062-30402| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVF
AIHKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLD
EEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDLVIY
QYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVSLTEEAEL
ELAENREILKTPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYARMRSAH
TNDVRQLTEVVQKIATESIVIWGRTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006