Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4062 | 4062-30402 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A, L90M | L33F, G73S | L10I, E34Q, N37H, R41K, I62V, L63P, C67W, A71V, I72F, V77I, I93L, C95V |
| >4062-30402| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKMIGGIGGFAKVRQYD QVPIEIWGHKVFSTVLIGPTPANIIGRNLMTQLGVTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, V75T, T215F | K219Q, N348I | V35T, K64H, V118I, K122E, D123E, I142V, E169D, I178L, I202V, F214L, L228H, A272S, I293V, P294S, E312T, I341IF, G359S, K366R, A371V, K385R |
| >4062-30402| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVF AIHKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLD EEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDLVIY QYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVSLTEEAEL ELAENREILKTPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYARMRSAH TNDVRQLTEVVQKIATESIVIWGRTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |