Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4059 | 4059-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, L210W, T215Y | K103N, Y181C, G190A | A98G | T39A, K43Q, E44D, V118I, K122E, I142V, I178M, T200A, V245Q, A272P, K275KR, I293V, P294AS, E297EAKT, E328EG, Y339W, R358K, G359S, A371V |
| >4059-30318| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYMDDLYVASDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVSLTTEAE LELAENREILKEPVHGVYYDPSKDLIAGIQKQGQGQWTWQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84V, L90M | G73S | L10I, T12S, I15V, L19T, K20V, M36MI, D60E, L63P, A71V, I72IT |
| >4059-30318| codons 1-99 PQITLWQRPIVSIKVGGQTVEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYE QIPIEICGHKVTSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |