Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4058 | 4058-30311 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | N348I | V35IM, T39A, K43E, K49KQ, W88CS, V118I, I202V, E203D, R211K, I293V, I329V, Q334E, K390R |
| >4058-30311| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISQIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVDELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L24I, Q58E, N83D | L10I, I13IV, K20R, A22V, E35D, M36I, N37Q, I62V, L63P, I64V, A71V, I72V, T91S, I93L |
| >4058-30311| codons 1-99 PQITLWQRPIVTVKIGGQLREVLIDTGADDTVLEDIQLPGRWKPKIIGGIGGFVKVREYD QVPVEICGHKVVGTVLVGPTPVDVIGRNLLSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |