Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4055 | 4055-30303 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82T, I84V | L24I | L10I, I13V, K20M, E35D, M36I, L63P, A71V, I72V |
| >4055-30303| codons 1-99 PQITLWQRPIVTVKIGGQLMEALIDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVVGTVLVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | F77L | K103N | A98G | V35M, K43N, V118I, K122E, D123G, E169D, R211K, L228R, I293V, D324E, I326V, R358K, G359GS, K390R |
| >4055-30303| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLMDLRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |