Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4052 | 4052-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33F | L10I, G16E, K20R, M36I, N37D, K45V, R57K, I62V, L63R, C67Y, K70T, L89M |
| >4052-30218| codons 1-99 PQITLWQRPIVTIKIEGQLREALIDTGADDTVFEEIDLPGRWKPVMIGGIGGFVKVKQYD QVRIEIYGHTAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, T215Y | K103NS, Y188L | V35T, T39A, K43Q, K102E, V118I, D177E, Q207E, R211K, D237A, V245K, A272P, V276I, L283I, A288T, I293V, E297K, L301I, I309IV, Q334E, V365I, K390R, I393V, K395R, E399D |
| >4052-30218| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEQEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKESKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLLVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPAKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKTLTEVVPLTKEAE IELAENREVLKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPVQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |