<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4051 4051-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y   L100I, K103N V108I K20R, E28K, K32E, V35I, E40F, K43E, V60I, A98S, T107S, V118I, K122E, Q174R, G196E, T200A, E203K, Q207E, R211K, H221Y, K223T, L228H, V245VM, A272P, K277R, I293V, E297R, V317A, I329V, Q334L, K350R, G359S, A371V, E399D  
>4051-30218| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICTFLEEEGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVSILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
YQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGFYTPDKKYQTEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, L76V, I84V, L90M L10F, G73T, L89V K20I, N37D, R41K, F53Y, K55KR, Q61H, L63P, A71V, T74S, V77I, I85IV, I93L  
>4051-30218| codons 1-99
PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEEMDLPGKWKPKIVGGIGGYMRVRQYD
HIPIEICGHKVITSVVIGPTPVNVVGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006