Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4051 | 4051-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, I84V, L90M | L10F, G73T, L89V | K20I, N37D, R41K, F53Y, K55KR, Q61H, L63P, A71V, T74S, V77I, I85IV, I93L |
| >4051-30218| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEEMDLPGKWKPKIVGGIGGYMRVRQYD HIPIEICGHKVITSVVIGPTPVNVVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | V108I | K20R, E28K, K32E, V35I, E40F, K43E, V60I, A98S, T107S, V118I, K122E, Q174R, G196E, T200A, E203K, Q207E, R211K, H221Y, K223T, L228H, V245VM, A272P, K277R, I293V, E297R, V317A, I329V, Q334L, K350R, G359S, A371V, E399D |
| >4051-30218| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICTFLEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVSILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGFYTPDKKYQTEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |