<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4049 4049-30217 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70G, Y115F, Q151M, M184V A62V, V75I, F77L     S68N, K122E, E138A, R172RK, Q207QR, F214L, A272P, T286TA, A288S, V292I, I293V, E297K, K311KR, Q334HN, R356K, M357T, K366R, T369TA, E370ED, I375IV  
>4049-30217| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FVIKKKDNTGWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSINNATPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRRHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEIVPLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKTRGA
HTNDVRQLADAVQKVATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54A, V82A   L10I, T12TS, L19I, K20R, M36I, R57K, Q61N, I62IV, L63P, I64V, C67CY, K70E, A71V, I72V, I93L  
>4049-30217| codons 1-99
PQITLWQRPIVSIKIGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGVGGFAKVKQYD
NVPVEIYGHEVVGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006