Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4049 | 4049-30217 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, Y115F, Q151M, M184V | A62V, V75I, F77L | S68N, K122E, E138A, R172RK, Q207QR, F214L, A272P, T286TA, A288S, V292I, I293V, E297K, K311KR, Q334HN, R356K, M357T, K366R, T369TA, E370ED, I375IV |
| >4049-30217| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDNTGWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRRHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEIVPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKTRGA HTNDVRQLADAVQKVATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L10I, T12TS, L19I, K20R, M36I, R57K, Q61N, I62IV, L63P, I64V, C67CY, K70E, A71V, I72V, I93L |
| >4049-30217| codons 1-99 PQITLWQRPIVSIKIGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGVGGFAKVKQYD NVPVEIYGHEVVGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |