Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4047 | 4047-30625 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | Q58E, G73S, L89V | L10I, V11L, I15V, G16A, K20IT, E21Q, M36MI, R41K, D60E, Q61D, L63P, A71V, I72T, I85V, I93L | T91CS |
| >4047-30625| codons 1-99 PQITLWQRPILTIKVAGQLTQALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVREYE DIPIEICGHKVTSTVLVGPTPTNVVGRNVMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184I, T215F | D67G, K219Q | Y181C | A98G, V108I, V179E, F227L | K20R, V35T, K64H, T69N, W88C, K103R, V118I, K122E, D123N, S162SDGN, I178L, T200A, E203K, Q207E, F214L, K223E, V245VE, A272P, K277R, I293V, S322T, I329L, Q334E, R358K, A360V, K390R, K395R, E399D |
| >4047-30625| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVF AIHKKGSNRWRKLVDFRELNKRTQDFCEVQLGIPHPGGLKKRKSVTILDVGDAYFSIPLD ENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDLEIC QYIDDLYVGSDLEIGQHRAKIKELREHLLRWGLFTPDQKHQEEPPLLWMGYELHPDKWTV QPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAEL ELAENREILKEPVHGVYYDPTKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARMKGVH TNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |