Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4046 | 4046-40304 | Germany | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184V | A62V, D67T, T69G, V75I, F77L, F116Y, K219R | K103N, Y181C | V35T, W88S, V118I, K122E, I135T, E138EG, I202V, R211K, F214L, V245E, A272P, K277R, I293V, T296S, E297K, I329L, M357T, V365I, A376T, T377L, T386A, K390R, E399D |
| >4046-40304| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FVIKRKTSGKWRKLIDLRELNKRTQDFSEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPL DEDFRKYTAFTIPSTNNGTPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLTTPDRKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLSKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDIKQLTEAVQKITLESIVIWGKAPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L33F, K43T, N83D | T4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93L |
| >4046-40304| codons 1-99 PQIALWQRPLVPVRIGGQLKEVLLDTGADDTVFREANLQGRWTPKIIGGIGGFVKVRQYE QVPIEICGYKVIGTVLVGPTPVDVIGRNLLSKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |