<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4040 4040-30512 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215F K219E Y181C   K49R, V60I, K101Q, K122E, S162C, E169D, G196E, D218E, L228H, A272P, K277R, T286A, T290TS, I293V, E297K, E298D, D324E, M357V, A360T, T369V, I393M, Q394L  
>4040-30512| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPI
FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALSEVVPLTKDAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGT
HTNDVKQLVEAVQKIATESIVIWGKTPKFKLPMLKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54M, I84V, L90M L10F, L33F, G73S, L89V I13V, G16E, K20V, M36L, R41RK, I62V, L63H, A71V  
>4040-30512| codons 1-99
PQITLWQRPFVTVKIEGQLVEALLDTGADDTVFEELNLPGKWKPKMIGGIGGFMKVRQYD
QVHIEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006