Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4040 | 4040-30512 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219E | Y181C | K49R, V60I, K101Q, K122E, S162C, E169D, G196E, D218E, L228H, A272P, K277R, T286A, T290TS, I293V, E297K, E298D, D324E, M357V, A360T, T369V, I393M, Q394L |
| >4040-30512| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALSEVVPLTKDAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGT HTNDVKQLVEAVQKIATESIVIWGKTPKFKLPMLKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, I84V, L90M | L10F, L33F, G73S, L89V | I13V, G16E, K20V, M36L, R41RK, I62V, L63H, A71V |
| >4040-30512| codons 1-99 PQITLWQRPFVTVKIEGQLVEALLDTGADDTVFEELNLPGKWKPKMIGGIGGFMKVRQYD QVHIEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |