<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4039 4039-30317 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50V, I54V, I84V, L90M V11I, L89V L10I, I13V, K20I, E35D, M36I, N37D, L63P, C67F, H69R, A71L, T91TS, Q92K  
>4039-30317| codons 1-99
PQITLWQRPIITVKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGVGGFVKVRQYD
QIPIEIFGRKLIGTVLVGPTPVNVIGRNVMSKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N     P4S, V35I, T39A, E44D, V60I, V118I, K122E, D123N, I142V, S162C, Q174H, G196E, T200TA, Q207E, R211K, D218DE, V245T, A272P, K277R, T286A, I293V, E297R, G333E, Q334L, R358K, G359S, A371V, T386I, K390R, E399D  
>4039-30317| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKHNPDIVI
YQYVDDLYVGSDLEIEQHRAKIEELREHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQELGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006