Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4039 | 4039-30317 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, I54V, I84V, L90M | V11I, L89V | L10I, I13V, K20I, E35D, M36I, N37D, L63P, C67F, H69R, A71L, T91TS, Q92K |
| >4039-30317| codons 1-99 PQITLWQRPIITVKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGVGGFVKVRQYD QIPIEIFGRKLIGTVLVGPTPVNVIGRNVMSKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | P4S, V35I, T39A, E44D, V60I, V118I, K122E, D123N, I142V, S162C, Q174H, G196E, T200TA, Q207E, R211K, D218DE, V245T, A272P, K277R, T286A, I293V, E297R, G333E, Q334L, R358K, G359S, A371V, T386I, K390R, E399D |
| >4039-30317| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKHNPDIVI YQYVDDLYVGSDLEIEQHRAKIEELREHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQELGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |