Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2081 | CA7705 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 56 |
| 2 | AZT+DDC | 52 |
| 3 | 3TC+AZT+SQV | 17 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | 3TC+D4T+NFV | 21 |
| 6 | 3TC+D4T+DDI+NVP | 54 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82VA, L90M | L33LI, G73S | L10I, K20MV, E35D, M36I, N37D, I62V, L63P, A71V, I72IL |
| >CA7705| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219KR | K103KN, V106VA, G190GA | F227FL | K20KR, T39TK, K43E, E44AD, W88C, K102Q, V118I, K122E, G196E, E203DV, Q207E, H208Y, R211K, H221HY, I293IV, E297Q | N54I |
| >CA7704| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEAGKISKIGPEIPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKQNKSATVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIDELREYLWKWGFYTPDRKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTQEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |