Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4037 | 4037-30313 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54L, V82A, L90M | L33F, G73S, L89V | L10I, V11VL, I15IV, K20RT, E35D, M36I, N37D, K55N, I62IV, L63P, K70KE, A71V |
| >4037-30313| codons 1-99 PQITLWQRPILTIKVGGQLTEALLDTGADDTIFEDIDLPGRWKPKIIGGIGGFLNVRQYD QVPIEICGHEVISTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69AD, K70R, L74I, V75T, M184MV, T215F | K219Q, N348I | K103N, Y181C, G190A | V179FY | T39A, K122E, I142IV, T165TI, G196K, T200A, I202V, D218E, H221HY, L228H, V245T, K277R, T286A, E297R, R356RK, M357MV, R358K, A376AT, K390R, Q394L, A400AT |
| >4037-30313| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIYI CQYVDDLYVASDLEIKQHRAKVEELRQHLLRWGFFTPEQKYQKEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKVKGA HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |