<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4037 4037-30313 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54L, V82A, L90M L33F, G73S, L89V L10I, V11VL, I15IV, K20RT, E35D, M36I, N37D, K55N, I62IV, L63P, K70KE, A71V  
>4037-30313| codons 1-99
PQITLWQRPILTIKVGGQLTEALLDTGADDTIFEDIDLPGRWKPKIIGGIGGFLNVRQYD
QVPIEICGHEVISTVLVGPTPANIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69AD, K70R, L74I, M184MV, T215F V75T, K219Q, N348I K103N, Y181C, G190A V179FY T39A, K122E, I142IV, T165TI, G196K, T200A, I202V, D218E, H221HY, L228H, V245T, K277R, T286A, E297R, R356RK, M357MV, R358K, A376AT, K390R, Q394L, A400AT  
>4037-30313| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIYI
CQYVDDLYVASDLEIKQHRAKVEELRQHLLRWGFFTPEQKYQKEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKVKGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006