Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4036 | 4036-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, M184V, L210W, T215Y | K219KR | K103N | A98G, V108I | K20KR, V35I, T39A, K43Q, E44D, K101KQ, V118I, K122E, D123E, I142V, S162C, K173Q, D177E, I178L, G196E, E203K, R211DH, K223Q, A272P, K277R, V292I, I293V, E297R, D324P, R356K, A360IT, S379C, K388Q |
| >4036-30218| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKNKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRQQNPELVI YQYVDDLYVGSDLEIEQHRTKIKELRQHLWHWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTREAE LELAENREILKEPVHGVYYDPSKPLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKIATECIVIWGKTPQFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47V, G48V, I54M, V82A, L90M | L33LF, K43KT | L10V, T12S, G16GA, E34EK, L63P, A71V, V77I, I93L |
| >4036-30218| codons 1-99 PQITLWQRPVVSIKIAGQLKEALLDTGADDTIFKEMNLPGRWTPKIVVGIGGFMKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |