<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4036 4036-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46MI, I47V, G48V, I54M, V82A, L90M L33LF, K43KT L10V, T12S, G16GA, E34EK, L63P, A71V, V77I, I93L  
>4036-30218| codons 1-99
PQITLWQRPVVSIKIAGQLKEALLDTGADDTIFKEMNLPGRWTPKIVVGIGGFMKVRQYD
QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74IV, M184V, L210W, T215Y K219KR K103N A98G, V108I K20KR, V35I, T39A, K43Q, E44D, K101KQ, V118I, K122E, D123E, I142V, S162C, K173Q, D177E, I178L, G196E, E203K, R211DH, K223Q, A272P, K277R, V292I, I293V, E297R, D324P, R356K, A360IT, S379C, K388Q  
>4036-30218| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKNKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRQQNPELVI
YQYVDDLYVGSDLEIEQHRTKIKELRQHLWHWGFYTPDRKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTREAE
LELAENREILKEPVHGVYYDPSKPLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLTEAVQKIATECIVIWGKTPQFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006