<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4035 4035-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82F L33F, Q58E L10I, E35D, M36L, I62V, L63P, I64V, A71V, V77I, I93L  
>4035-30218| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEDLNLPGRWKPKIIGGIGGFVKVREYD
QVPVEICGHKVIGTVVIGPTPFNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219N L100I, K103KN   E28K, K32E, T39A, E40F, K43E, V118I, D123E, I142IT, S163A, D177DG, I178IL, G196E, T200A, H208Y, R211K, W212M, D218E, L228H, Q242H, V245VA, A288S, I293V, V317VA, D324E, M357T, R358K, V365I, A371V, I375V, A376S, K390R  
>4035-30218| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSAMTKILEPFRKQNPGLVI
YQYMDDLYVGSDLEIEQHRAKIEELRQYLWKMGFYTPENKHQKEPPFHWMGYELHPDKWT
VHPIALPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGAYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDIKQLTEVVQKVSTESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006