Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4035 | 4035-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F | L33F, Q58E | L10I, E35D, M36L, I62V, L63P, I64V, A71V, V77I, I93L |
| >4035-30218| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEDLNLPGRWKPKIIGGIGGFVKVREYD QVPVEICGHKVIGTVVIGPTPFNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | L100I, K103KN | E28K, K32E, T39A, E40F, K43E, V118I, D123E, I142IT, S163A, D177DG, I178IL, G196E, T200A, H208Y, R211K, W212M, D218E, L228H, Q242H, V245VA, A288S, I293V, V317VA, D324E, M357T, R358K, V365I, A371V, I375V, A376S, K390R |
| >4035-30218| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSAMTKILEPFRKQNPGLVI YQYMDDLYVGSDLEIEQHRAKIEELRQYLWKMGFYTPENKHQKEPPFHWMGYELHPDKWT VHPIALPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDIKQLTEVVQKVSTESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |