<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4034 4034-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, M184V, T215F D67H, K219Q   A98G V35M, K43N, V60I, T69N, V118I, D123E, I135T, D177E, Q197H, F214L, Q278H, T286A, I293V, E297A, D324DE, G359S, A371T, T386TI, K390R, E399D, A400S  
>4034-30218| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPI
FAIKKKHSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGHHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTETVQKIATESIVIWGKIPKFRLPIQKETWDS

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54S, V82A, L90M L10F, L33F T12P, I13V, I62IV, L63P, A71V, I72V, Q92K, I93L, C95F  
>4034-30218| codons 1-99
PQITLWQRPFVPVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFSKVRQYD
QVPIEICGHKVVGTVLVGPTPANIIGRNLMTKLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006