Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4034 | 4034-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67H, K219Q | A98G | V35M, K43N, V60I, T69N, V118I, D123E, I135T, D177E, Q197H, F214L, Q278H, T286A, I293V, E297A, D324DE, G359S, A371T, T386TI, K390R, E399D, A400S |
| >4034-30218| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPI FAIKKKHSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGHHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTETVQKIATESIVIWGKIPKFRLPIQKETWDS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54S, V82A, L90M | L10F, L33F | T12P, I13V, I62IV, L63P, A71V, I72V, Q92K, I93L, C95F |
| >4034-30218| codons 1-99 PQITLWQRPFVPVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFSKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLMTKLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |