Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4032 | 4032-30414 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LV, L210W, T215Y | K219N | K103N, Y181C | E6K, K122E, Q174R, I178M, T200A, Q207E, R211K, I257L, V261I, I293V, K311R, V317A, I329V, Q334N, G335GD, G359S, A371V, A376S, K390R |
| >4032-30414| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDMVI CQYMDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLIGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGAYYDPSKDLIAEVQKQGNDQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33I | L10I, I13V, K20T, M36L, R41K, I62IV, L63P, I64V, T74E, L89LM, Q92K |
| >4032-30414| codons 1-99 PQITLWQRPIVTVKIGGQLTEALLDTGADDTVIEELNLPGKWKPKIIGGIGGFVKVRQYD QVPVEICGHKAIGEVLVGPTPVNVIGRNMMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |