Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4031 | 4031-30305 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, L210W, T215Y | K219E | K103N | V108I | V35IM, T39A, S68G, V118I, K122E, D123N, I135T, I142IV, D177DG, T200TA, E203K, Q207E, R211K, D218E, K223T, L228H, R284K, T286A, A288T, E297R, D324E, I326IM, I329L, M357MI, A360V, A376AT, S379C, E399D | P4PHNT |
| >4031-30305| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEIGQHRAKIKELREHLWKWGFYTPEEKHQTEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKTLTEVIPLTREAE LELAENREILKEPVHGVYYDPSKELMAELQKQGQGQWTYQIYQEPFKNLKTGKYARIRGV HTNDVKQLTEAVQKITTECIVIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I50IV, I54V, V82A, L90LM | L10FI, L24LI, L33LF, F53FL, G73GS | T4TP, I13IV, K14KR, I15V, Q18QH, K20R, E35D, M36I, N37E, R41K, I62IV, L63P, A71IT, I72IM, I85IV |
| >4031-30305| codons 1-99 PQIPLWQRPIVTVRVGGHLREALIDTGADDTVFEDIELPGKWKPKLIGGVGGLVKVRQYD QVPIEICGHKTMSTVLVGPTPANIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |