Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4030 | 4030-30227 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | L33LF, Q58E, G73S | L10I, L19LV, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72R, I93L |
| >4030-30227| codons 1-99 PQITLWQRPIVTIKIGGQVREALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVKVREYD QVPIEICGHKVRSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | K103S, G190A | P4T, E44D, K102KR, V118I, K122E, Q207K, R211A, D250E, A272P, E291D, I293V, E312EK, Q334I, G335S, M357T, G359S, A371V, K390R |
| >4030-30227| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELRKHLWAWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE LELAENREILKKPVHGVYYDPSKDLIAEIQKQGISQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |