Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4028 | 4028-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, G73T | I13A, Q18H, L19LV, K20I, E34Q, M36I, N37D, Q61R, L63P, I64V, I66V, A71T, I72V |
| >4028-30318| codons 1-99 PQITLWQRPFVTAKIGGHVIEALLDTGADDTVLQEIDLPGRWKPKIVGGIGGFMKVRQYD RIPVEVCGHKTVTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219Q | K103KN | K43N, K64R, V118I, K122E, I142V, D177N, G196E, T200I, H208Y, R211K, D218E, L228Q, V245VE, E248D, D250E, A272P, K281R, E297K, G359S, A371T, S379C, E399D |
| >4028-30318| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIEQHRIKIEELRQYLWKWGFYTPEQKHQKEPPFQWMGYELHPDKWT VQPIELPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTETVQKIATECIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |