<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4028 4028-30318 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, I84V, L90M L10F, G73T I13A, Q18H, L19LV, K20I, E34Q, M36I, N37D, Q61R, L63P, I64V, I66V, A71T, I72V  
>4028-30318| codons 1-99
PQITLWQRPFVTAKIGGHVIEALLDTGADDTVLQEIDLPGRWKPKIVGGIGGFMKVRQYD
RIPVEVCGHKTVTTVLVGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75T, M184V, L210W, T215Y K219Q K103KN   K43N, K64R, V118I, K122E, I142V, D177N, G196E, T200I, H208Y, R211K, D218E, L228Q, V245VE, E248D, D250E, A272P, K281R, E297K, G359S, A371T, S379C, E399D  
>4028-30318| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYVDDLYVGSDLEIEQHRIKIEELRQYLWKWGFYTPEQKHQKEPPFQWMGYELHPDKWT
VQPIELPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTETVQKIATECIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006