Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4027 | 4027-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, V82A, L90M | L33F, Q58E | L10I, I13IV, I15V, K20KR, E35D, M36I, R41RK, K55KR, I62IV, L63P, A71V, I93L |
| >4027-30318| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDINLPGKWKPKLIGGVGGFIRVREYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LIV, M184V, L210W, T215Y | K219N | K103N, Y181C, G190A | A98G | T39D, E44ED, S48T, V60I, V118I, K122P, I135IV, D177E, V179VI, H208HY, R211K, L228HR, K277R, Q278H, A288S, I293V, E312EA, I329L, Q334E, M357T, Q373QH |
| >4027-30318| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICDELEKDGKITKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKSLTEVVPLTEEAE LELAENREILKAPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVHKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |