<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4027 4027-30318 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I50V, V82A, L90M L33F, Q58E L10I, I13IV, I15V, K20KR, E35D, M36I, R41RK, K55KR, I62IV, L63P, A71V, I93L  
>4027-30318| codons 1-99
PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDINLPGKWKPKLIGGVGGFIRVREYD
QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LIV, M184V, L210W, T215Y K219N K103N, Y181C, G190A A98G T39D, E44ED, S48T, V60I, V118I, K122P, I135IV, D177E, V179VI, H208HY, R211K, L228HR, K277R, Q278H, A288S, I293V, E312EA, I329L, Q334E, M357T, Q373QH  
>4027-30318| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICDELEKDGKITKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKAPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVHKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006