<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4026 4026-30318 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M L10F, L33F, K43T, G73S, T74P, L89V G16E, N37D, K55R, I62V, L63H, C67F, H69HR, K70R, A71V G40G_KR
>4026-30318| codons 1-99
PQITLWQRPFVTIKIEGQLKEALLDTGADDTVFEEMDLPGRWTPKIIGGIGGFVRVRQYD
QVHIEIFGRRVISPVLVGPTPTNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y V75VL, K219N Y181C, G190A K101H, V108I K43Q, E44D, V60VI, K64R, V118I, D123E, T139K, S162SN, K166KR, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, K277R, R284K, I293V, E297A, S322A, M357T, R358K, V365I, K395R, E399D  
>4026-30318| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIRKKNSTKWRKVLDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSIPL
DKEFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPEMVI
CQYVDDLYVASDLEIGQHRAKIKELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006