Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4025 | 4025-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V, L90M | L33F, T74P | L10I, I13V, K20R, M36I, I62V, L63P, I64M, A71V, I93L, C95F |
| >4025-30318| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEEINLPGRWKPKMIGGIGGFVKVRQYD QVPMEICGHKVIGPVLVGPTPTNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, T215F | K219Q | Y181C, G190GA | V108VI | K20R, K43Q, V60I, K122E, R211K, D218E, L228H, V245E, I293V, E297K, R356K, R358K, G359S, A371T |
| >4025-30318| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKSA HTNDVKQLTETVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |