<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4024 4024-30630 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74I, T215F K219Q K101E, Y181C, G190A   K20R, K43KQ, K122E, I135V, S162Y, I167V, Q174QK, I195L, T200A, E204D, D218E, L228H, V245M, K277R, Q278E, L283I, E297K, S322T, I329L, R356K, G359S, K390R, T397I, E399D  
>4024-30630| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEQEGKISKIGPENPYNTPV
FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKVLEPFRKKNPDIVI
CQYMDDLYVASDLELGQHRAKIEDLRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLIRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKEIWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, I84V, L90M L10F, V11I, L33F, L89V K14R, I15V, K20V, M36IL, R41K, L63P, C67CY, A71I, I85V, Q92K E35H
>4024-30630| codons 1-99
PQITLWQRPFITIRVGGQLVEALLDTGADDTIFEHLNLPGKWKPKIVGGIGGFLKVRQYD
QIPIEIYGHKIIGTVLVGPTPVNVVGRNVMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006