Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4024 | 4024-30630 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, T215F | K219Q | K101E, Y181C, G190A | K20R, K43KQ, K122E, I135V, S162Y, I167V, Q174QK, I195L, T200A, E204D, D218E, L228H, V245M, K277R, Q278E, L283I, E297K, S322T, I329L, R356K, G359S, K390R, T397I, E399D |
| >4024-30630| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEQEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKVLEPFRKKNPDIVI CQYMDDLYVASDLELGQHRAKIEDLRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLIRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKEIWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10F, V11I, L33F, L89V | K14R, I15V, K20V, M36IL, R41K, L63P, C67CY, A71I, I85V, Q92K | E35H |
| >4024-30630| codons 1-99 PQITLWQRPFITIRVGGQLVEALLDTGADDTIFEHLNLPGKWKPKIVGGIGGFLKVRQYD QIPIEIYGHKIIGTVLVGPTPVNVVGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |