<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4022 4022-30326 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75L K101E, G190A   S3C, K43E, E44A, K122E, E138Q, I142V, S162C, I167V, I178L, H208F, R211K, D237E, V245K, T286TA, E297R, I326V, Q334E, R356K, R358K, S379C, K390R  
>4022-30326| codons 1-400
PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNQTPGVRYQYNVLPQGWKGSPAIFQCSMTKVLEPFRKQNPDLVI
YQYVDDLYVASDLEIGQHRTKIEELRQFLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMKGA
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82A, I84V, L90M L33F L10I, I13IV, N37Y, R41K, I62V, L63P, A71V, V77VI, T91TS, I93L, C95F  
>4022-30326| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMYLPGKWKPKLIGGIGGFLKVRQYD
QVPIEICGHKVIGTVLIGPTPANVIGRNLMSQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006