Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4022 | 4022-30326 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, I84V, L90M | L33F | L10I, I13IV, N37Y, R41K, I62V, L63P, A71V, V77VI, T91TS, I93L, C95F |
| >4022-30326| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMYLPGKWKPKLIGGIGGFLKVRQYD QVPIEICGHKVIGTVLIGPTPANVIGRNLMSQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75L | K101E, G190A | S3C, K43E, E44A, K122E, E138Q, I142V, S162C, I167V, I178L, H208F, R211K, D237E, V245K, T286TA, E297R, I326V, Q334E, R356K, R358K, S379C, K390R |
| >4022-30326| codons 1-400 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNQTPGVRYQYNVLPQGWKGSPAIFQCSMTKVLEPFRKQNPDLVI YQYVDDLYVASDLEIGQHRTKIEELRQFLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMKGA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |