Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4020 | 4020-30317 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, K43T | K55R, R57K, L63P, I64V |
| >4020-30317| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVRVKQYD QIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219N | K103KN, Y181YC | K238T | E6K, E53D, S68G, V118I, K122E, I142IV, S162AD, T200TK, R211K, D218DE, A272P, K277R, E297KR, I326IV, K350KR, R356RK, G359S, V365I, K366R, A371V, T386I, A400T |
| >4020-30317| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPDNPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRKKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDIRQLTEVVQKIATESIVIWGKIPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |