Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4019 | 4019-30311 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215F | K219Q, N348I | K101E, Y181C, G190A | S3C, E6K, K20R, T69N, K122E, Q207E, R211T, D218E, V245T, I293V, Q334L, R356K, K366R, A376T, K390R, E399D |
| >4019-30311| codons 1-399 PICPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELREHLLTWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKILKTGKYAKMRGA HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54A, V82A, L90M | L33F, K43KT, F53L, G73C | L10I, I13V, G16A, L19I, E34Q, K55R, L63P, A71V, I72M |
| >4019-30311| codons 1-99 PQITLWQRPIVTVKIAGQIKEALLDTGADDTVFQEMNLPGRWTPKIIGGVGGLARVRQYD QIPIEICGHKVMCTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |