<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4018 4018-30227 Germany 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74V, Y115F, M184V K219Q K103N, Y181C, G190A   K11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I  
>4018-30227| codons 1-399
PISPIETVPVTLKPGVDGPRVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL
HEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMIKILEPFRARNPEIVI
CQYVDDLYVASDLEIEQHRAKIEELRAHLLRWGLTTPDQKYQKEPPFRWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVRQLTEVVQKVSTESIIIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I L10F, V11I, L24I, L33F, Q58E, T74P T12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89M  
>4018-30227| codons 1-99
PQITLWQRPFIAVKIGGQLKEALIDTGADDTVFEDVDLPGRWKPKIIGGIGGFIKVREYD
QVTIEICGKRAIGPVLVGPTPVNIVGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006