Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4018 | 4018-30227 | Germany | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L10F, V11I, L24I, L33F, Q58E, T74P | T12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89M |
| >4018-30227| codons 1-99 PQITLWQRPFIAVKIGGQLKEALIDTGADDTVFEDVDLPGRWKPKIIGGIGGFIKVREYD QVTIEICGKRAIGPVLVGPTPVNIVGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V, Y115F, M184V | K219Q | K103N, Y181C, G190A | K11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I |
| >4018-30227| codons 1-399 PISPIETVPVTLKPGVDGPRVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL HEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMIKILEPFRARNPEIVI CQYVDDLYVASDLEIEQHRAKIEELRAHLLRWGLTTPDQKYQKEPPFRWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVRQLTEVVQKVSTESIIIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |