Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4015 | 4015-30415 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | D67G, T215A, K219E | L100I, K103N | S68G, I135T, T165L, D177E, T200A, F214L, V245M, A272P, I293V, L295LF, S322A, Q334D, G335S, P345Q, R356K, M357T, A376V, T386I |
| >4015-30415| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLATPDEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPFTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGDSQWTYQIYQEQFKNLKTGKYAKTRGA HTNDVKQLTEAVQKIVTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, E35D, N37S, L63P, I64V, I72V, V77I |
| >4015-30415| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |