<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4014 4014-30408 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y V75M, K219R K103KNRS, G190A V108I E6D, K20R, V21I, K43E, E44A, V60I, I94L, V118I, K122E, V189I, Q197K, H208Y, R211K, K223Q, V245E, A272PS, T286A, A288AS, I293V, E297A, D324E, Q334E, A355S, M357T, R358K, T369V, E370G, S379G, V381I, K390R L228Y
>4014-30408| codons 1-399
PISPIDTVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYIASDLEIGKHRTKIEELRQYLWKWGFYTPDRKHQQEPPFYWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKSLTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYSRTKGA
HTNDVKQLVGAVQKIATEGIIIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I84V, L90M L10F, V11I, G73C, L89V I13V, I15V, G16AE, K20V, I62V, L63T, I64V, C67F, T74E, V77VI, P79A  
>4014-30408| codons 1-99
PQITLWQRPFITVKVEGQLVEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD
QVTVEIFGHKAICEVLIGATPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006