Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4014 | 4014-30408 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V, L90M | L10F, V11I, G73C, L89V | I13V, I15V, G16AE, K20V, I62V, L63T, I64V, C67F, T74E, V77VI, P79A |
| >4014-30408| codons 1-99 PQITLWQRPFITVKVEGQLVEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QVTVEIFGHKAICEVLIGATPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K219R | K103KNRS, G190A | V108I | E6D, K20R, V21I, K43E, E44A, V60I, I94L, V118I, K122E, V189I, Q197K, H208Y, R211K, K223Q, V245E, A272PS, T286A, A288AS, I293V, E297A, D324E, Q334E, A355S, M357T, R358K, T369V, E370G, S379G, V381I, K390R | L228Y |
| >4014-30408| codons 1-399 PISPIDTVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYIASDLEIGKHRTKIEELRQYLWKWGFYTPDRKHQQEPPFYWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYSRTKGA HTNDVKQLVGAVQKIATEGIIIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |