<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4013 4013-30408 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, V75T, L210W, T215Y K219N L100I, K103N   V35I, E40F, K43E, K49R, A98S, V118I, D121C, K122E, T200K, Q207E, H208Y, R211K, L228H, V245M, A272AP, T286A, I293V, E297A, Q334P, K347KR, M357R, G359S, A371V  
>4013-30408| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISRIGPENPYNTPV
FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL
CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRKKIEELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPGQWTYQIYQEPFRNLKTGKYARRRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82A, L90M Q58E L10I, K20R, E35D, M36I, N37E, K55KR, R57RK, D60E, L63P, A71V, I72V, I93L  
>4013-30408| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGIGGFARVKEYE
QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006