Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4013 | 4013-30408 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A, L90M | Q58E | L10I, K20R, E35D, M36I, N37E, K55KR, R57RK, D60E, L63P, A71V, I72V, I93L |
| >4013-30408| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGIGGFARVKEYE QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75T, L210W, T215Y | K219N | L100I, K103N | V35I, E40F, K43E, K49R, A98S, V118I, D121C, K122E, T200K, Q207E, H208Y, R211K, L228H, V245M, A272AP, T286A, I293V, E297A, Q334P, K347KR, M357R, G359S, A371V |
| >4013-30408| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISRIGPENPYNTPV FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRKKIEELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPGQWTYQIYQEPFRNLKTGKYARRRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |